GrippeEspagneV1, Main, Exploration, bibRecord, 000174

Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study.

Identifieur interne : 000174 ( Main/Exploration ); précédent : 000173; suivant : 000175

Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study.

Auteurs : Josep Montserrat-Capdevila [Espagne] ; Pere Godoy [Espagne] ; Josep Ramon Marsal [Espagne] ; Ferran Barbé [Espagne] ; Leonardo Galván [Espagne]

Source :

BMC family practice [ 1471-2296 ] ; 2015.

RBID : pubmed:26642879

Descripteurs français

KwdFr :
- Appréciation des risques (méthodes), Broncho-pneumopathie chronique obstructive (thérapie), Broncho-pneumopathie chronique obstructive (épidémiologie), Connaissances, attitudes et pratiques en santé (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Morbidité (tendances), Mâle (MeSH), Odds ratio (MeSH), Soins de santé primaires (méthodes), Sujet âgé (MeSH), Études de suivi (MeSH), Études rétrospectives (MeSH), Évolution de la maladie (MeSH).
MESH :
- méthodes : Appréciation des risques, Soins de santé primaires.
- tendances : Morbidité.
- thérapie : Broncho-pneumopathie chronique obstructive.
- épidémiologie : Broncho-pneumopathie chronique obstructive, Espagne.
- Connaissances, attitudes et pratiques en santé, Facteurs de risque, Femelle, Humains, Indice de gravité de la maladie, Mâle, Odds ratio, Sujet âgé, Études de suivi, Études rétrospectives, Évolution de la maladie.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Aged (MeSH), Disease Progression (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Health Knowledge, Attitudes, Practice (MeSH), Humans (MeSH), Male (MeSH), Morbidity (trends), Odds Ratio (MeSH), Primary Health Care (methods), Pulmonary Disease, Chronic Obstructive (epidemiology), Pulmonary Disease, Chronic Obstructive (therapy), Retrospective Studies (MeSH), Risk Assessment (methods), Risk Factors (MeSH), Severity of Illness Index (MeSH), Spain (epidemiology).
MESH :
- geographic , epidemiology : Spain.
- epidemiology : Pulmonary Disease, Chronic Obstructive.
- methods : Primary Health Care, Risk Assessment.
- therapy : Pulmonary Disease, Chronic Obstructive.
- trends : Morbidity.
- Aged, Disease Progression, Female, Follow-Up Studies, Health Knowledge, Attitudes, Practice, Humans, Male, Odds Ratio, Retrospective Studies, Risk Factors, Severity of Illness Index.

Abstract

BACKGROUND

The risk of exacerbation in chronic obstructive pulmonary disease (COPD) depends on the severity of disease and other less well known factors. Predictive models of exacerbation are more accurate than the forced expiratory volume in one second (FEV1). The objective was to design a model that predicts the risk of exacerbation in COPD.

METHODS

Retrospective cohort study with data from the electronic medical records of patients diagnosed with COPD in the province of Lleida (Spain). A total of 2501 patients were followed during 3 years. The dependent variable was acute exacerbation; independent variables were: clinical parameters, spirometry results, severity of disease, influenza and 23-valent pneumococcal immunisation, comorbidities, smoking and history of exacerbation. The association of these variables with disease exacerbation was measured by the adjusted odds ratio using a logistic regression model.

RESULTS

Mean age at the start of the study was 68.38 years (SD = 11.60) and 74.97% patients were men; severity of disease was considered mild in 50.82% of patients, moderate in 35.31%, severe in 9.44% and very severe in 4.44%. During the three year study period up to 83.17% of patients experienced at least one exacerbation. Predictive factors in the model were age, gender, previous exacerbations, influenza and 23-valent pneumococcal immunisations, number of previous visits to the General Practice and severity (GOLD), with an area under the ROC curve (AUROC) of 0.70.

CONCLUSIONS

This model can identify patients at high risk of acute exacerbation. Preventive measures and modification of treatment in these high-risk patients would improve survival.

DOI: 10.1186/s12875-015-0387-6
PubMed: 26642879
PubMed Central: PMC4672528

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Health Knowledge, Attitudes, Practice</term>
<term>Humans</term>
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<term>Odds Ratio</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
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<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Odds ratio</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The risk of exacerbation in chronic obstructive pulmonary disease (COPD) depends on the severity of disease and other less well known factors. Predictive models of exacerbation are more accurate than the forced expiratory volume in one second (FEV1). The objective was to design a model that predicts the risk of exacerbation in COPD.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Retrospective cohort study with data from the electronic medical records of patients diagnosed with COPD in the province of Lleida (Spain). A total of 2501 patients were followed during 3 years. The dependent variable was acute exacerbation; independent variables were: clinical parameters, spirometry results, severity of disease, influenza and 23-valent pneumococcal immunisation, comorbidities, smoking and history of exacerbation. The association of these variables with disease exacerbation was measured by the adjusted odds ratio using a logistic regression model.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Mean age at the start of the study was 68.38 years (SD = 11.60) and 74.97% patients were men; severity of disease was considered mild in 50.82% of patients, moderate in 35.31%, severe in 9.44% and very severe in 4.44%. During the three year study period up to 83.17% of patients experienced at least one exacerbation. Predictive factors in the model were age, gender, previous exacerbations, influenza and 23-valent pneumococcal immunisations, number of previous visits to the General Practice and severity (GOLD), with an area under the ROC curve (AUROC) of 0.70.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>This model can identify patients at high risk of acute exacerbation. Preventive measures and modification of treatment in these high-risk patients would improve survival.</p>
</div>
</front>
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<Month>08</Month>
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<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12875-015-0387-6</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The risk of exacerbation in chronic obstructive pulmonary disease (COPD) depends on the severity of disease and other less well known factors. Predictive models of exacerbation are more accurate than the forced expiratory volume in one second (FEV1). The objective was to design a model that predicts the risk of exacerbation in COPD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Retrospective cohort study with data from the electronic medical records of patients diagnosed with COPD in the province of Lleida (Spain). A total of 2501 patients were followed during 3 years. The dependent variable was acute exacerbation; independent variables were: clinical parameters, spirometry results, severity of disease, influenza and 23-valent pneumococcal immunisation, comorbidities, smoking and history of exacerbation. The association of these variables with disease exacerbation was measured by the adjusted odds ratio using a logistic regression model.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean age at the start of the study was 68.38 years (SD = 11.60) and 74.97% patients were men; severity of disease was considered mild in 50.82% of patients, moderate in 35.31%, severe in 9.44% and very severe in 4.44%. During the three year study period up to 83.17% of patients experienced at least one exacerbation. Predictive factors in the model were age, gender, previous exacerbations, influenza and 23-valent pneumococcal immunisations, number of previous visits to the General Practice and severity (GOLD), with an area under the ROC curve (AUROC) of 0.70.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This model can identify patients at high risk of acute exacerbation. Preventive measures and modification of treatment in these high-risk patients would improve survival.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Montserrat-Capdevila</LastName>
<ForeName>Josep</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Biomedical Research Institute (IRB) of Lleida, Lleida, Catalonia, Spain. jmontser@alumni.unav.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Health Department, Public Health Agency of Catalonia, Lleida, Catalonia, Spain. jmontser@alumni.unav.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Catalan Institute of Health (ICS), Mollerussa/Lleida, Catalonia, Spain. jmontser@alumni.unav.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Godoy</LastName>
<ForeName>Pere</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Biomedical Research Institute (IRB) of Lleida, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Health Department, Public Health Agency of Catalonia, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, University of Lleida, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marsal</LastName>
<ForeName>Josep Ramon</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Lleida Research Support Unit, Primary Care Research Institute (IDIAP) Jordi Gol. Autonomous University of Barcelona, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cardiovascular Department, Epidemiology Unit, University Hospital Vall d'Hebron, Barcelona, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barbé</LastName>
<ForeName>Ferran</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Biomedical Research Institute (IRB) of Lleida, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Catalan Institute of Health (ICS), Mollerussa/Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, University of Lleida, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pneumology Unit, University Hospital Arnau de Vilanova, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Biomedical Research Centre Network for Respiratory Diseases (CIBERES), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galván</LastName>
<ForeName>Leonardo</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Pharmacy Unit. Catalan Health Service, Lleida, Catalonia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>12</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Fam Pract</MedlineTA>
<NlmUniqueID>100967792</NlmUniqueID>
<ISSNLinking>1471-2296</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007722" MajorTopicYN="Y">Health Knowledge, Attitudes, Practice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009017" MajorTopicYN="N">Morbidity</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011320" MajorTopicYN="N">Primary Health Care</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029424" MajorTopicYN="N">Pulmonary Disease, Chronic Obstructive</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>03</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>11</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>12</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Day>9</Day>
<Hour>6</Hour>
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</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>8</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
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<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2000 May;161(5):1608-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10806163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respiration. 2000;67(5):495-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11070451</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2009;4:233-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19554194</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Med. 2009 Mar;103(3):373-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19013781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Med. 2009 Oct;103(10):1461-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19515547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Esp Quimioter. 2009 Nov;22 Suppl 1:26-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20084346</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Bronconeumol. 2009;45 Suppl 5:14-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20116757</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 Sep 16;363(12):1128-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20843247</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2011;6:521-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22069363</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2011;12:151</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22082049</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2012 Jan;39(1):38-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21737561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2012 Jan;141(1):94-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2013;8:259-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23754870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2013 Jun 12;309(22):2390-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23757089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2013;8:493-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24143086</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fam Pract. 2013 Dec;30(6):621-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24115012</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2013;8:551-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24348031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Radiat Oncol. 2014;9:26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24422711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Enferm Infecc Microbiol Clin. 2014 Feb;32(2):70-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23582192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>COPD. 2014 Aug;11(4):381-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24111845</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Environ Res Public Health. 2014 Nov;11(11):11822-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25405599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2015;10:201-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25670896</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Chron Obstruct Pulmon Dis. 2015;10:823-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25977604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Bronconeumol. 2002 Jun;38(6):256-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12113741</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2002 Oct;57(10):847-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12324669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2002 Dec;57(12):1067-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12454303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J Suppl. 2003 Jun;41:46s-53s</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12795331</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Care. 2003 Dec;48(12):1204-13; discussion 1213-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14651761</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 1997 May 24;349(9064):1498-504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9167458</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1418-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9603117</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 1998 Sep;53(9):803-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10319066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2006;(1):CD002733</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16437444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2006 Mar;61(3):250-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16517585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2006;7:74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16686949</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2007 Jan;62(1):5-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17189530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2007 Sep 15;176(6):532-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17507545</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2008 Feb 15;177(4):396-401</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18048806</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2008 Nov;63(11):951-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18535116</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
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Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study.

Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study.

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